Publications and Awards
Selected Publications
- Shahani P, Mahadevan A, Mondal K, Waghmare G, Datta I. Repeat intramuscular transplantation of human dental pulp stromal cells is more effective in sustaining Schwann cell survival and myelination for functional recovery after onset of diabetic neuropathy. Cytotherapy. 2023 Nov;25(11):1200-1211. doi: 10.1016/j.jcyt.2023.07.011. Epub 2023 Aug 26.
- Raj A, Banerjee R, Santhoshkumar R, Sagar C, Datta I*. Presence of Extracellular Alpha-Synuclein Aggregates Trigger Astrocytic Degeneration Through Enhanced Membrane Rigidity and Deregulation of Store-Operated Calcium Entry (SOCE) into the Endoplasmic Reticulum. Mol Neurobiol. 2023 Jun 8. doi: 10.1007/s12035-023-03400-0. Epub 2023 Jun 8.
- Banerjee R, Raj A, Potdar C, Pal PK, Yadav R, Kamble N, Holla V, Datta I*. Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery. Cells 2023, 12(12), 1592; https://doi.org/10.3390/cells12121592. Published: 8 June 2023
- Jagtap S, Potdar C, Yadav R, Pal PK, Datta I*. Dopaminergic Neurons Differentiated from LRRK2 I1371V-Induced Pluripotent Stem Cells Display a Lower Yield, α-Synuclein Pathology, and Functional Impairment. ACS Chem Neurosci. 2022 Sep 7;13(17):2632-2645. doi: 10.1021/acschemneuro.2c00297. Epub 2022 Aug 25.
- Potdar C, Kaushal A, Raj A, Mallick R, Datta I*. Reduction of phosphorylated α-synuclein through downregulation of casein kinase 2α alleviates dopaminergic-neuronal function. Biochem Biophys Res Commun. 2022 May 11;615:43-48. doi: 10.1016/j.bbrc.2022.05.023.
- Jagtap S, Sowmithra, Yadav R, Pal PK, Datta I*. Generation of induced pluripotent stem cells (NIMHi004-A, NIMHi005-A and NIMHi006-A) from healthy individuals of Indian ethnicity with no mutation for Parkinson’s disease related genes. Stem Cell Res. 2022; Apr 60:102716. doi: 10.1016/j.scr.2022.102716. Epub 2022 Feb 23.
- Raj A, Kaushal A, Datta I*. Impact of monomeric and aggregated wild type and A30P/A53T double mutant α-synuclein on anti-oxidant mechanism and glutamate metabolic profile of cultured astrocytes. Journal of Neuroscience Research. 2021; (In press.)
- Nandakumar S, Shahani P, Datta I, Pal R. Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead? ACS Chem Neurosci. 2021; Oct 20;12(20):3785-3794. doi: 10.1021/acschemneuro.1c00525. Epub 2021 Oct 9.
- Shahani P, Mahadevan A, Datta I*. Fundamental changes in endogenous bone marrow mesenchymal stromal cells during Type I Diabetes is a pre-neuropathy event. Biochim Biophys Acta Mol Basis Dis. 2021; Available online 5 June 2021, 166187.
- Shahani P, Datta I*. Mesenchymal stromal cell therapy for coronavirus disease 2019: Which? When? And how much? Cytotherapy. 2021; Apr 30:S1465-3249(21)00234-6. doi: 10.1016/j.jcyt.2021.04.004.
- Sowmithra S, Bhonde R, Datta I*. Recovery of human embryonic stem cells-derived neural progenitors exposed to hypoxic-ischemic-reperfusion injury by indirect exposure to Wharton’s Jelly mesenchymal stem cells through Phosphatidyl-inositol-3-Kinase pathway. Cellular and Molecular Neurobiology. 2020. Online ahead of print.
- Shahani P, Kaushal A, Waghmare G, Datta I*. Biodistribution of intramuscularly transplanted human Dental Pulp Stem Cells in immunocompetent healthy rats through Near Infra-Red imaging. Cells Tissues Organs. 2020; 17;1-12.
- Datta I*, Jagtap S, Sowmithra S, Yadav R, Pal PK. Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003-A) from two sporadic Parkinson’s disease patient of East Indian ethnicity. Stem Cell Res. 2020;49:101995.
- Datta I*, Sowmithra S, Jagtap S, Potdar C, Yadav R, Pal P. Generation of induced pluripotent stem cells (NIMHi001-A) from a Parkinson’s disease patient of East Indian ethnicity carrying LRRK2 I1371V variant. Stem Cell Res. 2020; 44:101768.
- Datta I*, Mekha SR, Kaushal A, Ganapathy K, Razdan R. Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(2):147-165.
- Datta I*, Ganapathy K, Razdan R, Bhonde R. Location and Number of Astrocytes Determine Dopaminergic Neuron Survival and Function Under 6-OHDA Stress Mediated Through Differential BDNF Release. Mol Neurobiol. 2018; 55(7):5505-5525.
- Datta I*, Bhadri N, Shahani P, Majumdar D, Sowmithra S, Razdan R, Bhonde R. Functional recovery upon human dental pulp stem cell transplantation in a diabetic neuropathy rat model. Cytotherapy. 2017; 19(10):1208-1224.
- Ganapathy K, Datta I*, Sowmithra S, Joshi P, Bhonde R. Influence of 6-Hydroxydopamine Toxicity on α-Synuclein Phosphorylation, Resting Vesicle Expression and Vesicular Dopamine Release. J Cell Biochem. 2016; 117(12):2719-2736.
- Majumdar D, Kanafi M, Bhonde R, Gupta P, Datta I*. Differential Neuronal Plasticity of Dental Pulp Stem Cells from Exfoliated Deciduous and Permanent Teeth towards Dopaminergic Neurons. J Cell Physiol. 2016; 231(9):2048-63.
- Datta I*, Mishra S, Mohanty L, Pulikkot S, Joshi PG. Neuronal plasticity of human Wharton’s Jelly mesenchymal stromal cells to the dopaminergic cell type compared with human bone marrow mesenchymal stromal cells. Cytotherapy. 2011; 13(8):918-32.
Book Chapters
- Datta I*, Majumdar D, Ganapathy K. “Stem Cells and Neuronal differentiation”, Stem Cell Therapy for Organ Failures, Springer Publishers. 2014.
- Datta I* and Ganapathy K. “Modification of Alpha-Synuclein by Phosphorylation: A Pivotal Event in the Cellular Pathogenesis of Parkinson’s Disease”, Phosphorylation, InTech Publishers. 2016.
- Datta I*, Kaushal A, Raj A. “Role of astrocyte dysfunction in Parkinson’s Disease pathogenesis”, Glial Biology: Role of Glia in Health and Disease. Springer Publishers. 2021 (in process).
Honors and achievements
- BIRAC PACE Grant awardee (2018).
- Awarded the Innovative Young Biotechnologist Award by DBT, in the subject area of ‘Stem cells and Neuroscience’ (2013-2014).
- Awarded Fast Track Scheme For Young Scientists from Department of Science and Technology, Government of India (2010).
- Travel grant award from International society of stem cell and research (ISSCR), Philadelphia, USA (2008).
- Awarded Senior Research Fellowship, Lady Tata Memorial Trust Scholarship (2004).
*Corresponding author
Stem cells derived from human exfoliated deciduous teeth (SHED) in neuronal disorders: A Review
Current stem cell Research & Threapy
Recovery of human embryonic stem cells-derived neural progenitors exposed to hypoxic-ischemic-reperfusion injury by indirect exposure to Wharton’s Jelly mesenchymal stem cells through Phosphatidyl-inositol-3-Kinase pathway.
Biodistribution of intramuscularly transplanted human Dental Pulp Stem Cells in immunocompetent healthy rats through Near Infra-Red imaging.
Generation of induced pluripotent stem cells (NIMHi002-A and NIMHi003- A) from two sporadic Parkinson's disease patient of East Indian ethnicity
Generation of induced pluripotent stem cells (NIMHi001-A) from a Parkinson's disease patient of East Indian ethnicity carrying LRRK2 I1371V variant
Generation of induced pluripotent stem cells (NIMHi001-A) from a Parkinson's disease patient of East Indian ethnicity carrying LRRK2 I1371V variant
Neonatal Hypoxic-Ischemic Injury Using Neural Progenitors Derived from Human Embryonic Stem Cells.
Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model.
Human adipose tissue mesenchymal stem cells as a novel treatment modality for correcting obesity induced metabolic dysregulation.
Astrocytes-like cells differentiated from dental pulp stem cells protect dopaminergic neurons against 6-hydroxydopamine toxicity.
Location and Number of Astrocytes Determine Dopaminergic Neuron Survival and Function Under 6-OHDA Stress Mediated Through Differential BDNF Release.
Functional recovery upon human dental pulp stem cell transplantation in a diabetic neuropathy rat model.
By changing dimensionality, Sequential culturing of midbrain cells by changing dimensionality generates neuron-glial ratio akin to in vivo adult midbrain than 2-dimensional culture.
Influence of 6-Hydroxydopamine Toxicity on α-Synuclein Phosphorylation, Resting Vesicle Expression and Vesicular Dopamine Release.
Differential Neuronal Plasticity of Dental Pulp Stem Cells from Exfoliated Deciduous and Permanent Teeth towards Dopaminergic Neurons.
Midbrain dictates the fate of human dental pulp stem cells.
Influence of ischemic microenvironment on human Wharton's Jelly mesenchymal stromal cells
Directed differentiation of human embryonic stem cell-line HUES9 to dopaminergic neurons in a serum-free defined culture niche
Cell therapy: the final frontier for treatment of neurological diseases
Can mesenchymal stem cells reduce vulnerability of dopaminergic neurons in the substantia nigra to oxidative insult in individuals at risk to Parkinson's disease?
Neuronal plasticity of human Wharton's Jelly mesenchymal stromal cells to the dopaminergic cell type compared with human bone marrow mesenchymal stromal cells
NMDA and non-NMDA receptor mediated differential Ca2+ load and greater vulnerability of motor neurons in spinal cord cultures
Cerebrospinal fluid from amyotrophic lateral sclerosis patients preferentially elevates intracellular calcium and toxicity in motor neurons via AMPA/Kainate receptor
